Author： Lobanov A. V. Rzhevskii D. I. Korshunov V. A. Murashev A. N.
Publisher： Springer Publishing Company
ISSN： 0007-4888
Source： Bulletin of Experimental Biology and Medicine, Vol.137, Iss.2, 2004-02, pp. : 111-113
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Abstract
We studied the effects of blockade of nicotinic receptors in sympathetic and parasympathetic ganglia (hexamethonium), muscarinic receptors (atropine), and β1-adrenoceptors (atenolol) on arrhythmogenic activity of endothelin-1 during inhibition of nitric oxide synthesis with Nω-nitro-L-arginine in NMRI mice. Atropine reduced, while hexamethonium completely abolished the arrhythmogenic effect of endothelin-1 during nitric oxide synthase inhibition. Atenolol potentiated arrhythmogenic activity of Nω-nitro-L-arginine, but endothelin-1 had no effect on the incidence of arrhythmias under these conditions.
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