Lunar Soil Simulant Uptake Produces a Concentration-Dependent Increase in Inducible Nitric Oxide Synthase Expression in Murine RAW 264.7 Macrophage Cells

Author： Chatterjee Anuran Wang Angela Lera Matthew Bhattacharya Sharmila

Publisher： Taylor & Francis Ltd

ISSN： 1087-2620

Source： Journal of Toxicology and Environmental Health, Vol.73, Iss.9, 2010-01, pp. : 623-626

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Abstract

One of NASA's long-term objectives is to be able to stay on the moon for extended periods, and to provide a stepping-stone for future Mars explorations. The lunar soil simulant JSC-1 has been developed by NASA from volcanic ash found in Arizona to facilitate testing of toxicity and system requirements for lunar exploration. A concentration-response study of JSC-1 was undertaken on the murine macrophage cell line RAW 264.7. Results demonstrated concentrations of 50-2000 μ g/ml JSC-1 induced enhanced expression of inducible nitric oxide synthase (iNOS). Data suggest that extraterrestrial regolith has the potential to induce an inflammatory response, and that future development of anti-inflammatory mitigative strategies may be necessary to counteract lunar dust-associated cellular toxicity.