Author： Gisch N. Balzarini J. Meier C.
Publisher： Taylor & Francis Ltd
ISSN： 1525-7770
Source： Nucleosides, Nucleotides & Nucleic Acids, Vol.26, Iss.6-7, 2007-06, pp. : 861-864
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Abstract
A new class of "lock-in"-modified cycloSal-pronucleotides has been synthesized. On the example of 5-diacetoxymethyl-cycloSal-d4T-monophosphate (5-di-AM-cycloSal-d4TMP), the concept of enzymatically activated cycloSal-pronucleotides is elucidated. Synthesis, hydrolysis studies, and antiviral activities against HIV are presented.
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