Publisher： Bentham Science Publishers
E-ISSN： 1875-6255|8|9|668-673
ISSN： 1570-1786
Source： Letters in Organic Chemistry, Vol.8, Iss.9, 2011-11, pp. : 668-673
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Abstract
Synthesis of Sildenafil by the O-alkylation of 5-[2-hydroxy-5-(4-methylpiperazin-1-ylsulphonyl)phenyl]-1- methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo-[4,3-d]pyrimidin-7-one 8 proved difficult because concomitant alkylation of the pyrimidine moity also occurred. The selective O-alkylation was carried by DCC assisted decarboxilative etherification of the carbonate 9.
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