Publisher： John Wiley & Sons Inc
E-ISSN： 1613-4133|59|4|784-794
ISSN： 1613-4125
Source： MOLECULAR NUTRITION & FOOD RESEARCH, Vol.59, Iss.4, 2015-04, pp. : 784-794
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Abstract
ScopeGreen tea (GT) consumption helps to prevent and control obesity by stimulating hepatic lipid metabolism. However, GT‐induced changes in serum and liver metabolomes associated with the anti‐obesity effects are not clearly understood. The aim of this study was to identify and validate metabolomic profiles in the livers and sera of GT‐fed obese mice to elucidate the relationship between GT consumption and obesity prevention.Methods and resultsSerum and liver metabolites were analyzed in mice fed normal diet, high‐fat diet (HFD), HFD with GT, and HFD with crude catechins, using LC‐quadrupole TOF MS. The addition of 1% GT to HFD reduced adipose tissue and the levels of blood triglycerides, glucose, insulin, and leptin elevated in HFD‐fed mice. We proposed an HFD‐induced obesity pathway and validated it by investigating the key regulatory enzymes of mitochondrial β‐oxidation: carnitine palmitoyltransferase‐1 and ‐2, acyl‐coenzyme A dehydrogenase, and acetyl‐coenzyme A acyltransferase. The results showed that HFD‐induced abnormal mitochondrial β‐oxidation was moderated by the consumption of caffeine‐ and theanine‐enriched GT.ConclusionResults of LC/MS‐based metabolomic analysis of obese mice showed changes associated with abnormal lipid and energy metabolism, which were alleviated by GT intake, indicating the mechanism underlying the anti‐obesity effects of GT.
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