Aryl λ3‐Iodane‐Mediated 6‐exo‐trig Cyclization to Synthesize Highly Substituted Chiral Morpholines

Publisher： John Wiley & Sons Inc

E-ISSN： 1615-4169|357|13|2788-2794

ISSN： 1615-4150

Source： ADVANCED SYNTHESIS & CATALYSIS, Vol.357, Iss.13, 2015-09, pp. : 2788-2794

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Abstract

AbstractA mild and efficient transition metal‐free approach has been developed for the synthesis of highly substituted chiral morpholines from alkenols by amino acid‐derived iodine(III) reagents via a 6‐exo‐trig cyclization. The key features of this work include the formation of three chiral centers with a high diastereomeric ratio, broad functional group compatibility, and atom/time economic methodology.

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