Author： Schreiber H. Wu T.H. Nachman J. Rowley D.A.
Publisher： Academic Press
ISSN： 1044-579X
Source： Seminars in Cancer Biology, Vol.10, Iss.5, 2000-10, pp. : 351-357
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Abstract
While it has been known for decades that the growth of tumor transplants can be enhanced immunologically, the potential significance of these previous findings to the development of primary tumors and the mechanisms of tumor enhancement has remained obscure. This review will summarize recent experiments indicating that primary tumor development can be enhanced by active immunization. The evidence suggests that antibodies, B cells and CD4+T cells can play a critical role in enhancing the development of primary tumors, whereas endogenous interferon-gamma (IFN
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