Author： Mitchell R.A. Bucala R.
Publisher： Academic Press
ISSN： 1044-579X
Source： Seminars in Cancer Biology, Vol.10, Iss.5, 2000-10, pp. : 359-366
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Abstract
First identified nearly 40 years ago, macrophage migration inhibitory factor (MIF) is a potent pro-inflammatory cytokine and is an essential component of immune and inflammatory responses. Recent studies suggest that MIF may also contribute to multiple aspects of tumor progression and neoplasia. This review will attempt to summarize these findings focusing on MIF’s ability to modulate cell proliferation, tumor angiogenesis and tumor suppressor activity.
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