A seroprevalence study of poliovirus antibody against a collection of recombinant and non-recombinant poliovirus vaccine strains in the population of southern Greece

Author： Pliaka V. Ruether I. G. A. Kyriakopoulou Z. Kioussi P. Plakokefalos E. Megalou M. Pratti A. Levidiotou-Stefanou S. Markoulatos P.

Publisher： Blackwell Publishing

ISSN： 1198-743X

Source： Clinical Microbiology & Infection, Vol.16, Iss.11, 2010-11, pp. : 1672-1675

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Abstract

Clin Microbiol Infect 2010; 16: 1672–1675 AbstractIn this study, the serological status of the southern Greek population in the 1–10-year, 11–20-year, 21–30-year and 31–40 -year age groups with regard to Sabin vaccine strains and a collection of 15 recombinant and four non-recombinant poliovirus vaccine strains was determined. For all three poliovirus types, the highest neutralization test (NT) titres were observed in the 1–10-year age group, indicating a good response to vaccination. In general, the serological status of the population of southern Greece with regard to poliovirus is better for types 1 and 2 than for type 3. The presence of the lowest NT titre in the 21–30-year age group against poliovirus type 3 suggests the need for a booster dose of monovalent Sabin3 vaccine to ensure personal and herd immunity.