A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease

By McDonald David A.   Shenkar Robert   Shi Changbin   Stockton Rebecca A.   Akers Amy L.   Kucherlapati Melanie H.   Kucherlapati Raju   Brainer James   Ginsberg Mark H.   Awad Issam A.   Marchuk Douglas A.  

Human Molecular Genetics, Vol. 20, Iss. 2, 2011-01 ,pp. : 211-222

Oxford University Press

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Mutations in the gene encoding KRIT1, a Krev-1/rap1a binding protein, cause cerebral cavernous malformations ( CCM1 )

By Sahoo Trilochan   Johnson Eric W.  

Human Molecular Genetics, Vol. 8, Iss. 12, 1999-11 ,pp. : 2325-2333

Oxford University Press

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Conditional deletion of Ccm2 causes hemorrhage in the adult brain: a mouse model of human cerebral cavernous malformations

By Cunningham Kirk   Uchida Yutaka   O'Donnell Erin   Claudio Estefania   Li Wenling   Soneji Kosha   Wang Hongshan   Mukouyama Yoh-suke   Siebenlist Ulrich  

Human Molecular Genetics, Vol. 20, Iss. 16, 2011-08 ,pp. : 3198-3206

Oxford University Press

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CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis

By Zawistowski Jon S.  

Human Molecular Genetics, Vol. 14, Iss. 17, 2005-09 ,pp. : 2521-2531

Oxford University Press

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Biallelic somatic and germline mutations in cerebral cavernous malformations (CCMs): evidence for a two-hit mechanism of CCM pathogenesis

By Akers Amy L.   Johnson Eric   Steinberg Gary K.   Zabramski Joseph M.   Marchuk Douglas A.  

Human Molecular Genetics, Vol. 18, Iss. 5, 2009-03 ,pp. : 919-930

Oxford University Press

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