Protein Tyrosine Nitration: Role in Aging

E-ISSN： 1874-6128|10|4|246-262

ISSN： 1874-6098

Source： Current Aging Science, Vol.10, Iss.4, 2017-10, pp. : 246-262

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Abstract

Background: Aging is the inevitable fate of all living organisms, but the molecular basisof physiological aging is poorly understood. Oxidative stress is believed to play a key role in theaging process. In addition to Reactive Oxygen Species (ROS), Reactive Nitrogen Species (RNS)are generated during aerobic metabolism in living organisms. Although protein damage and functionalmodification by ROS have been demonstrated in details, fewer studies have been reported onprotein damage by RNS and its implication in the aging process. Proteins undergoing tyrosine nitrationare associated with pathophysiology of several diseases, as well as physiological aging. Thepurpose of the current review article is to provide a brief summary of the biochemical mechanismsof tyrosine nitration, methodologies used for the detection of these modified proteins, effect of RNSinduced post translational modification on biological functions and the putative role of tyrosine nitratedproteins in the aging process.lt;/Pgt