Combination of a Cyano Migration Strategy and Alkene Difunctionalization: The Elusive Selective Azidocyanation of Unactivated Olefins

Publisher： John Wiley & Sons Inc

E-ISSN： 1521-3757|128|36|10979-10982

ISSN： 0044-8249

Source： ANGEWANDTE CHEMIE, Vol.128, Iss.36, 2016-08, pp. : 10979-10982

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Abstract

AbstractA conceptually new, efficient, and metal‐free approach for the challenging azidocyanation of unactivated alkenes is presented. The strategy of intramolecular distal cyano migration is combined with alkene difunctionalization for the first time. A variety of useful azido‐substituted alkyl nitriles are prepared in good yields and, most importantly, with exquisite regio‐ and stereo‐selectivities.

Related content

Alkene 1,2‐Difunctionalization by Radical Alkenyl Migration

By  

ANGEWANDTE CHEMIE INTERNATIONAL EDITION, Vol. 57, Iss. 3, 2018-01 ,pp. : 814-817 (4)

John Wiley & Sons Inc

Access to resources Recommend Favorite

Alkene 1,2‐Difunctionalization by Radical Alkenyl Migration

By  

ANGEWANDTE CHEMIE, Vol. 130, Iss. 3, 2018-01 ,pp. : 822-825 (4)

John Wiley & Sons Inc

Access to resources Recommend Favorite

Oxime‐Mediated Oxychlorination and Oxybromination of Unactivated Olefins

By  

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Vol. 2015, Iss. 7, 2015-03 ,pp. : 1419-1422 (4)

John Wiley & Sons Inc

Access to resources Recommend Favorite

Nickel‐Catalyzed Insertion of Alkynes and Electron‐Deficient Olefins into Unactivated sp3 CH Bonds

By  

CHEMISTRY - A EUROPEAN JOURNAL, Vol. 21, Iss. 32, 2015-08 ,pp. : 11320-11324 (5)

John Wiley & Sons Inc

Access to resources Recommend Favorite

Distal Functional Group Migration for Visible‐light Induced Carbo‐difluoroalkylation/monofluoroalkylation of Unactivated Alkenes

By  

ADVANCED SYNTHESIS & CATALYSIS, Vol. 360, Iss. 4, 2018-02 ,pp. : 744-750 (7)

John Wiley & Sons Inc

Access to resources Recommend Favorite