Author： Michalak Karol Michalak Michał Wicha Jerzy
Publisher： MDPI
E-ISSN： 1420-3049|10|9|1084-1100
ISSN： 1420-3049
Source： Molecules, Vol.10, Iss.9, 2005-09, pp. : 1084-1100
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Abstract
Sesqui- and sesterterpenes of ophiobolin and fusicoccin families are important synthetic targets because of complexity of structure and potentially useful physiological activities, including anti-tumor activity. A synthesis of versatile building blocks for these terpenoids is described. Cyclopenta[8]annulene rings system with properly dislocated substituents was constructed using as key steps ring closing metathesis reaction and Wagner - Meerwein rearrangement. Ring closing metathesis reaction leading to cyclopenta[8]annulene was studied in detail.
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