Solventless Lactam Synthesis by Intramolecular Cyclizations of α-Iminoester Derivatives under Microwave Irradiation

Author： Zradni Fatima-Zohra   Hamelin Jack   Derdour Aicha  

Publisher： MDPI

E-ISSN： 1420-3049|12|3|439-454

ISSN： 1420-3049

Source： Molecules, Vol.12, Iss.3, 2007-03, pp. : 439-454

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Abstract

We have previously reported a new synthesis of amides from esters and amines under microwave irradiation, offering much higher yields than those achieved with conventional heating [1]. We have now extended these studies to the ring closure of neat iminoesters I2, I3 and I4-I6 to give five- and six-membered ring lactams L5, L6 and larger lactams L7-L9 (where I means imine and L means lactam), respectively, under both classical heating conditions and microwave irradiation.

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