Protective Effect of Cactus Cladode Extracts on Peroxisomal Functions in Microglial BV-2 Cells Activated by Different Lipopolysaccharides

Author： Saih Fatima-Ezzahra   Andreoletti Pierre   Mandard Stéphane   Latruffe Norbert   El Kebbaj M’Hammed Saïd   Lizard Gérard   Nasser Boubker   Cherkaoui-Malki Mustapha  

Publisher： MDPI

E-ISSN： 1420-3049|22|1|102-102

ISSN： 1420-3049

Source： Molecules, Vol.22, Iss.1, 2017-01, pp. : 102-102

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Abstract

In this study, we aimed to evaluate the antioxidant and anti-inflammatory properties of Opuntia ficus-indica cactus cladode extracts in microglia BV-2 cells. Inflammation associated with microglia activation in neuronal injury can be achieved by LPS exposure. Using four different structurally and biologically well-characterized LPS serotypes, we revealed a structure-related differential effect of LPS on fatty acid β-oxidation and antioxidant enzymes in peroxisomes: Escherichia coli-LPS decreased ACOX1 activity while Salmonella minnesota-LPS reduced only catalase activity. Different cactus cladode extracts showed an antioxidant effect through microglial catalase activity activation and an anti-inflammatory effect by reducing nitric oxide (NO) LPS-dependent production. These results suggest that cactus extracts may possess a neuroprotective activity through the induction of peroxisomal antioxidant activity and the inhibition of NO production by activated microglial cells.

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