Synthesis and cytotoxic activity of resveratrol-based compounds

Author： Handler Norbert  

Publisher： Springer Publishing Company

ISSN： 0026-9247

Source： Monatshefte für Chemie / Chemical Monthly, Vol.139, Iss.5, 2008-05, pp. : 575-578

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

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Abstract

In continuation of our studies on compounds with a resveratrol-based scaffold two compounds with N-containing functional groups have been synthesized and screened for their inhibitory effect on the growth of the human cancer cell lines HT29, 518A2, AsPC-1, BxPC-3, and PC-3. Compound 4, but not 1, demonstrated pronounced in vitro cytotoxicity against all these cancer cell lines, thus making this compound a promising candidate for further preclinical in vivo studies.

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