Author： Kittisak Likhitwitayawuid Boonchoo Sritularak Kanokwan Benchanak Vimolmas Lipipun Judy Mathew Raymond F. Schinazi
Publisher： Taylor & Francis Ltd
ISSN： 1478-6419
Source： Natural Product Research, Vol.19, Iss.2, 2005-02, pp. : 177-182
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
From the leaves of Millettia erythrocalyx , a new flavone named 3
,5-dimethoxy-[2,3 : 7,8]-furanoflavone and three known compounds were isolated. Assays for anti-herpes simplex virus activity (HSV-1 and HSV-2) were performed on 24 phenolic compounds obtained from M. erythrocalyx and Artocarpus lakoocha. It was found that the flavones ovalifolin, pongol methyl ether and millettocalyxin A, and the stilbene oxyresveratrol possessed moderate activity against both types of HSV. In addition, oxyresveratrol was evaluated for potential anti-HIV activity against a wild-type human immunodeficiency virus type 1 (HIV-1/LAI) isolate and was found to be a modest inhibitor of HIV (EC 50 28.2 µM), showing no toxicity in PBM, CEM and Vero cells at 100 µM. The heartwood of A. lakoocha , which contains a large amount of oxyresveratrol, could be considered as a source of starting material for the development of new natural product-based anti-HSV and anti-HIV agents.
Related content
Access to resources
Recommend
Flavonoids from Artocarpus Lanceifolius
By Cao Shugeng Butler Mark S. Buss Antony D.
Natural Product Letters, Vol. 17, Iss. 2, 2003-01 ,pp. :
Artomandin, a new xanthone from Artocarpus kemando (Moraceae)
Natural Product Research, Vol. 25, Iss. 10, 2011-06 ,pp. :
Prenylated 2-arylbenzofurans from Artocarpus petelotii
Natural Product Research, Vol. 22, Iss. 16, 2008-11 ,pp. :