Author： Ma Qi Shen Jun-Hui Shen Sheng-Rong Das Undurti N.
Publisher： Taylor & Francis Ltd
ISSN： 1040-8398
Source： Critical Reviews in Food Science and Nutrition, Vol.54, Iss.1, 2014-01, pp. : 1-16
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Abstract
Diabetic retinopathy is a common condition that occurs in patients with diabetes with long-standing hyperglycemia that is characterized by inappropriate angiogenesis. This pathological angiogenesis could be a sort of physiological proliferative response to injury by the endothelium. Recent studies suggested that reactive oxygen species (ROS) play a significant role in this angiogenesis. Vascular endothelial growth factor (VEGF) is a potent angiogenic growth factor that plays a significant role in diabetic retinopathy. The interaction between VEGF and ROS, and theirs in turn with pro- and anti-inflammatory cytokines and anti-inflammatory bioactive lipid molecules such as lipoxins, resolvins, protectins, and maresins is particularly relevant to understand the pathophysiology of diabetic retinopathy and develop future therapeutic interventions.
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