In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons

By Thomas Elizabeth A.   Coppola Giovanni   Tang Bin   Kuhn Alexandre   Kim SoongHo   Geschwind Daniel H.   Brown Timothy B.   Luthi-Carter Ruth   Ehrlich Michelle E.  

Human Molecular Genetics, Vol. 20, Iss. 6, 2011-03 ,pp. : 1049-1060

Oxford University Press

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Mutant huntingtin alters MAPK signaling pathways in PC12 and striatal cells: ERK1/2 protects against mutant huntingtin-associated toxicity

By Apostol Barbara L.   Illes Katalin   Pallos Judit   Bodai Laszlo   Wu Jun   Strand Andrew   Schweitzer Erik S.   Olson James M.   Kazantsev Aleksey   Marsh J. Lawrence  

Human Molecular Genetics, Vol. 15, Iss. 2, 2006-01 ,pp. : 273-285

Oxford University Press

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Striatal cells from mutant huntingtin knock-in mice are selectively vulnerable to mitochondrial complex II inhibitor-induced cell death through a non-apoptotic pathway

By Ruan Qingmin  

Human Molecular Genetics, Vol. 13, Iss. 7, 2004-04 ,pp. : 669-681

Oxford University Press

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Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage

By Kuhn Alexandre   Goldstein Darlene R.   Hodges Angela   Strand Andrew D.   Sengstag Thierry   Kooperberg Charles   Becanovic Kristina   Pouladi Mahmoud A.   Sathasivam Kirupa   Cha Jang-Ho J.   Hannan Anthony J.   Hayden Michael R.   Leavitt Blair R.   Dunnett Stephen B.   Ferrante Robert J.   Albin Roger   Shelbourne Peggy   Delorenzi Mauro   Augood Sarah J.   Faull Richard L.M.   Olson James M.   Bates Gillian P.   Jones Lesley   Luthi-Carter Ruth  

Human Molecular Genetics, Vol. 16, Iss. 15, 2007-08 ,pp. : 1845-1861

Oxford University Press

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Preferential accumulation of N-terminal mutant huntingtin in the nuclei of striatal neurons is regulated by phosphorylation

By Havel Lauren S.   Wang Chuan-En   Wade Brandy   Huang Brenda   Li Shihua   Li Xiao-Jiang  

Human Molecular Genetics, Vol. 20, Iss. 7, 2011-04 ,pp. : 1424-1437

Oxford University Press

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