Author： Özdemir Hasan Çiftçi Mehmet
Publisher： Informa Healthcare
ISSN： 1475-6366
Source： Journal of Enzyme Inhibition and Medicinal Chemistry, Vol.21, Iss.1, 2006-02, pp. : 75-80
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Abstract
In vitro effects of omeprazole, morphine sulphate, remifentanyl, ketamine and vankomycin were investigated on human red blood cell glucose-6 phosphate dehydrogenase (G-6PD) (E.C. 1.1.1.49) enzyme activity purified from human red blood cell by 2′, 5′ADP-Sepharose 4B affinity gel. The obtained I 50 values of omeprazole, morphine, remifentanil, ketamine and vankomycin were 3.24, 43.58, 97.6, 64.16 and 0.903 mM, respectively and the K i constants for omeprazole, morphine and vankomycin were 8.22 ± 2.055, 25.93 ± 6.482, and 2.71 ± 0.677 mM, respectively and they were non competitive inhibitors.
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