Author: Gonzalez-Vicente Agustin Cabral Pablo D. Hong Nancy J. Asirwatham Jessica Yang Nianxin Berthiaume Jessica M. Dominici Fernando P. Garvin Jeffrey L.
Publisher: MDPI
E-ISSN: 2072-6643|9|8|885-885
ISSN: 2072-6643
Source: Nutrients, Vol.9, Iss.8, 2017-08, pp. : 885-885
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Abstract
Fructose-enriched diets cause salt-sensitive hypertension. Proximal tubules (PTs) reabsorb 70% of the water and salt filtered through the glomerulus. Angiotensin II (Ang II) regulates this process. Normally, dietary salt reduces Ang II allowing the kidney to excrete more salt, thereby preventing hypertension. We hypothesized that fructose-enriched diets enhance the ability of low concentrations of Ang II to stimulate PT transport. We measured the effects of a low concentration of Ang II (10−12 mol/L) on transport-related oxygen consumption (QO2), and Na/K-ATPase and Na/H-exchange (NHE) activities and expression in PTs from rats consuming tap water (Control) or 20% fructose (FRUC). In FRUC-treated PTs, Ang II increased QO2 by 14.9 ± 1.3 nmol/mg/min (
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